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While vitamin C and zinc proved ineffective as a treatment when clinically compared to standard care, the study of other therapeutics continues.” “As we watched the pandemic spread across the globe, infecting and killing millions, the medical community and consumers alike scrambled to try supplements that they believed could possibly prevent infection, or ease COVID-19 symptoms, but the research is just now catching up. “When we began this trial, there was no research to support supplemental therapy for the prevention or treatment of patients with COVID-19,” said Milind Desai, M.D., MBA, director, clinical operations in Cleveland Clinic’s Heart Vascular & Thoracic Institute and co-principal investigator of the study. Specifically the endpoint of a 50% reduction in symptoms showed no significant difference between the usual care, vitamin C, zinc gluconate or the group receiving both vitamin C and zinc gluconate. The study was stopped for futility, with no significant difference among the four groups. Patients were randomized and either received 10 days of zinc gluconate (50 mg), vitamin C (8000 mg), both agents, or standard of care from April 2020 to October 2020.
#MOST VITAMIN R USELESS TRIAL#
The COVIDAtoZ clinical trial enrolled 214 adult patients with a confirmed COVID-19 infection. Vitamin C, an antioxidant, can help reduce damage to cells, and has shown to be immune-boosting.
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It also has a role in antibody and white blood cell production and can fight infections. Zinc is known to be important for immune function. Since the start of the COVID-19 pandemic there has been widespread speculation about the role of various vitamins and supplements to prevent or treat it, but there remains limited scientific evidence. The study was published today in JAMA Open Network. Cleveland Clinic researchers have found that zinc or ascorbic acid (vitamin C) – or a combination of the two – do not significantly decrease the severity or duration of symptoms in COVID-19-positive patients, when compared to standard care.